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US 4,290,962 AGranted
Novel hydrocortisone derivative
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsYasuhide Tachi, Kazuhiko Michishita, Jozi Nakagami, Jiro Sawada, Mitsunori Washitake, Yoshiaki Kamano
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Abstract
17.alpha.-butyryloxy-11.beta.-hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or halide. The compound of the present invention has excellent anti-inflammatory effect, percutaneous absorption and less side effect.
Claims1
17.alpha.-buty ryloxy-11.beta.-hydroxy-21-propionyloxy-4-pregnen-3,20-dione.
Dependencies are inferred from the claim text.