Benzoxazepine derivatives and process for preparing the same
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsMasuo Koizumi, Kazuo Sasahara, Yasushi Murakami, Sakae Wada, Hiroshi Nakakimura, Noboru Kubodera, Shun-Ichi Hata
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Abstract
Dibenz[b,f][1,4]oxazepine derivatives represented by the formula ##STR1## [wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the specification], and a process for preparing the same are disclosed. The object compounds have excellent serum cholesterol lowering activity, serum lipid lowering activity, blood lipid peroxide lowering activity and anti-aggregation of platelet activity, and therefore are useful as a drug.
Claims24
A dibenzoxazepine derivative represented by the formula ##STR47## wherein R.sub.1 is hydrogen, a halogen, a lower alkyl group or a lower alkoxyl group;
- n is an integer of 1 or 2;
- R.sub.2 is a hydroxyl group, a lower alkoxyl group or a nuclear-substituted or unsubstituted anilino group;
- and R.sub.3 is hydrogen or an carboxylic group.
Dependencies are inferred from the claim text.