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US 4,290,952 AGranted
Aryl-1-mercaptoalkanoylproline and homoproline derivatives
AssigneeAmerican Home Products Corporation
InventorsMeier E. Freed, James L. Diebold
Life of this patent
Estimating the term…
Abstract
Aryl-1-mercaptoalkanoylproline and homoproline derivatives and their cyclized thiazadione heterocyclic analogues reduce blood pressure in animals by ACE inhibition.
Claims8
A compound of the formula:
- ##STR4## wherein R.sup.1 and R.sup.2, are independently, hydrogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms or halo;
- R.sup.3 is hydrogen or alkyl of one to six carbon atoms;
- R.sup.4 is hydrogen or alkyl of one to six carbon atoms;
- R.sup.5 is hydrogen, alkanoyl of two to six carbon atoms or benzoyl;
- R.sup.6 is --OH or --OM where M is a pharmaceutically acceptable cation;
- m is one of the integers 0 or 1;
- and
- n is one of the integers 0, 1 or 2.
5 more elements
A compound of the formula:
- ##STR5## wherein R.sup.1 and R.sup.2 are, independently, hydrogen or alkoxy of one to three carbon atoms;
- R.sup.3 is hydrogen or methyl
- R.sup.4 is hydrogen or alkyl of one to three carbon atoms;
- R.sup.5 is hydrogen, acetyl or benzoyl;
- and
- R.sup.6 is --OH or --OM where M is a pharmaceutically acceptable cation.
3 more elements
Dependencies are inferred from the claim text.