4A-Aryl-decahydroisoquinolines
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsHenry Rapoport, Dwight D. Weller, Richard D. Gless
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Abstract
This invention relates to the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl and intermediates. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine.
Claims5
A compound, tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyl-decahydroisoquinoline-7-carboxyla te (33).
A compound, 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline (9).
A compound, trans-.DELTA..sup.7 -6.alpha.-hydroxy-4a.alpha.-(3'-hydroxyphenyl)-2-methyloctahydroisoquinoli ne (6).
A compound, trans-.DELTA..sup.7 -6.alpha.-hydroxy-4a-(3'-methoxyphenyl-2-methyloctahydroisoquinoline (7).
A compound, .DELTA..sup.6 .DELTA..sup.8(8a) -6-methoxy-4a-(3'-methoxyphenyl)-2-methylhexahydroisoquinoline (8).
Dependencies are inferred from the claim text.