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US 4,289,879 AGranted
Synthetic method and intermediate for piroxicam
AssigneePfizer Inc.
InventorJoseph G. Lombardino
Life of this patent
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Abstract
2-Methoxyethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide is an advantageous ester precursor for piroxicam (4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide), an antiinflammatory agent established in medical practice.
Claims4
A compound of the formula ##STR10##
A process for converting an ester of the formula ##STR11## to piroxicam which comprises reacting said ester with 2-aminopyridine in a reaction-inert organic solvent at 115.degree.-175.degree. C. until the reaction is substantially complete.
Dependencies are inferred from the claim text.