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US 4,289,877 AGranted
2-Decarboxy-2-tetrazolyl-9-deoxy-5,9.alpha.-epoxy-4,5-cis-17,18 -tetradehydro-PGF.sub.1 compounds
AssigneeThe Upjohn Company
InventorRoy A. Johnson
Life of this patent
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Abstract
The present invention relates to novel 2-decarboxy-2-tetrazolyl-9-deoxy-5,9.alpha.-epoxy-4,5-cis-17,18-tetra dehydro-PGF.sub.1 compounds, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.
Claims16
A compound of the formula ##STR2## wherein W.sub.1 is .alpha.-OH:.beta.-H, .alpha.-H:.beta.-OH, oxo, methylene, .alpha.-H:.beta.-H, .alpha.-CH.sub.2 OH:.beta.-H;
- wherein L is
- (1) --(CH.sub.2).sub.d --C(R.sub.2).sub.2, or
- (2) --CH.dbd.CH--,
- wherein d is zero to 5, R.sub.2 is hydrogen, methyl, or fluoro, being the same or different with the proviso that one R.sub.2 is not methyl when the other is fluoro, and Y is a valence bond, --CH.sub.2 -- or --(CH.sub.2).sub.2 --,
- wherein Q is oxo, .alpha.-H:.beta.-H, .alpha.-OH:.beta.-R.sub.8 or .alpha.-R.sub.8 :.beta.-OH
- wherein R.sub.8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
- and
- wherein X is
- (1) trans-CH.dbd.CH--,
- (2) cis-CH.dbd.CH--,
- (3) --C.tbd.C--, or
- (4) --CH.sub.2 CH.sub.2 --;
- including the lower alkanoates thereof.
10 more elements
Dependencies are inferred from the claim text.