Antisecretory agents
AssigneeBristol-Myers Company
InventorsAldo A. Algieri, Ronnie R. Crenshaw
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.
Claims6
A compound of the formula ##STR34## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive;
- R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino;
- n is 2 or 3;
- X is NR.sup.3 or CHR.sup.3 ;
- R.sup.3 is SO.sub.2 Ar or SO.sub.2 (lower)alkyl;
- R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ;
- p is an integer of from 1 to 4, inclusive;
- R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl;
- and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl;
- or a nontoxic, pharmaceutically acceptable salt thereof.
A compound having the formula ##STR37## wherein R is selected from phenyl, 4-chlorophenyl, 4-methylphenyl, 3,4-dichlorophenyl and methyl, or a nontoxic pharmaceutically acceptable salt thereof.
A compound having the formula ##STR38## wherein R is selected from phenyl, 4-chlorophenyl, 4-methylphenyl, 3,4-dichlorophenyl and methyl, or a nontoxic pharmaceutically acceptable salt thereof.
1-Phenylsul fonyl-2-(2-propynylamino)-2-{2-[(3-bromo-2-pyridyl)methylthio]ethylamino}et hylene, or a nontoxic pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.