Back to results
US 4,289,851 AGranted
Process for producing cyclosporin derivatives
AssigneeSandoz Ltd.
InventorsRene P. Traber, Max Kuhn, Hans Hofmann, Eugen Harri
Life of this patent
Estimating the term…
Abstract
The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.
Claims1
A process for the production of a compound of formula I ##STR5## wherein A is ##STR6## hereinafter referred to as cyclosporin D, dihydroclosporin D or iso-cyclosporin D, respectively,
- which comprises
- (a) for the production of cyclosporin D, cultivating a cyclosporin D producing strain of the species Tolypocladium inflatum Gams in the presence of a nutrient medium and isolating cyclosporin D,
- (b) for the production of dihydrocyclosporin, hydrogenating cyclosporin D, or
- (c) for the production of isocyclosporin D rearranging cyclosporin D under acidic conditions.
1 more element
Dependencies are inferred from the claim text.