US 4,289,786 A · Farnesylacetic acid ester derivatives

Abstract

Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: ##STR1## wherein A is an alkylene radical containing at least 2 carbon atoms; R.sup.1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R.sup.2 and R.sup.3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R.sup.2 and R.sup.3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R.sup.2 and R.sup.3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R.sup.1, R.sup.2 and R.sup.3 is at least 5.

Claims20

Dependent claims

A farnesylacetic acid ester derivative selected from the group consisting of compounds represented by the general formula (I) ##STR71## wherein A is a straight or branched alkylene group having 2 to 10 carbon atoms in its principal chain,

R' is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 9 carbon atoms, or an alkenyl group having 2 to 15 carbon atoms, and
R.sup.2 and R.sup.3 are the same or different and each is a hydrogen atom or an alkyl group having 1 to 8 carbon atoms,
provided that the total number of carbon atoms contained in said A, R.sup.1, R.sup.2 and R.sup.3 groups is at least five;
and pharmaceutically acceptable salts thereof.

1 more element

Dependencies are inferred from the claim text.

Farnesylacetic acid ester derivatives

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Farnesylacetic acid ester derivatives

Life of this patent

Abstract

Claims20