Pyromellitic diimides and method of increasing feed efficiency in ruminant animals
AssigneeMerck & Co., Inc.
InventorsRichard J. Bochis, Michael H. Fisher, Bruce O. Linn
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Abstract
Novel substituted pyromellitic diimides are disclosed wherein the compounds are assymetrically substituted with a variety of substituent groups. Processes for the preparation of such compounds are also disclosed. The novel assymetrically substituted pyromellitic diimides are useful for administration to ruminant animals to increase feed efficiency, shift volatile fatty acid production in the ruminants from acetate with an increase in the more energetically efficient propionate and butyrate and to suppress methane formation in the rumen. Composition and methods of treatment utilizing said compounds as the active ingredient thereof are also disclosed.
Claims13
A compound having the formula:
- ##STR15## wherein R.sub.1 is hydrogen and R.sub.2 is loweralkyl, loweralkenyl, loweralkynyl, cycloalkyl, loweralkanoyl, benzoyl, substituted phenyl wherein the substituent is sulfonamido, hydroxy, carboxy, nitro, methylthio, or hydroxy loweralkyl;
- substituted loweralkyl wherein the substituents are one or two of hydroxy, halogen nitro, loweralkoxy, carboxy, phenyl, hydroxyloweralkoxy, loweralkanoyloxy, phenoxy, amino, mono- or di-loweralkylamino, mercapto, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkoxycarbonyl, carbamyl, hydroxyloweralkylthio, hydroxyloweralkylsulfinyl, hydroxyloweralkylsulfonyl, hydroxyloweralkylamino, di-(hydroxyloweralkyl)amino, loweralkanoylamino or hydroxyphenyl;
- diloweralkylamino, or mono-substituted amino wherein the substituent is loweralkanoyl, benzoyl or loweralkoxycarbonyl;
- and
- X and Y are independently hydrogen, loweralkyl or halogen.
Dependencies are inferred from the claim text.