Anti-psychotic phthalimidine derivatives
AssigneeAstra Lakemedel Aktiebolag
InventorsKarl S. Bengtsson, Seth O. Thorberg, Sven O. Ogren
Life of this patent
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Abstract
Compounds having antipsychotic activity, characterized by the formula ##STR1## in which formula R.sub.o and R.sub.1 are the same or different and are each selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl, and R.sub.2 is selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl, pharmaceutical compositions containing them, and a method for the treatment of psychoses.
Claims13
A compound of the formula ##STR27## and pharmaceutically acceptable acid-addition salts thereof, in which formula R.sub.0 and R.sub.1 are the same or different and are each selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl, and R.sub.2 is selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl.
A pharmaceutical preparation which comprises as active ingredient a therapeutically effective amount for the treatment of psychoses of a compound of the formula ##STR28## or a pharmaceutically acceptable acid-addition salt thereof, in which formula R.sub.0 and R.sub.1 are the same or different and are each selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl, and R.sub.2 is selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl, in association with a pharmaceutically acceptable carrier.
A method for the treatment of psychoses in man, characterized by the administration to a host in need of such treatment of a therapeutically effect amount of a compound of the formula ##STR29## or a pharmaceutically acceptable acid-addition salt thereof, in which formula R.sub.0 and R.sub.1 are the same or different and are each selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and tridluoromethyl, and R.sub.2 is selected from hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 or 3 carbon atoms, and trifluoromethyl.
Dependencies are inferred from the claim text.