Antibacterial compounds
AssigneeBeecham Group Limited
InventorsKong Luk, John P. Clayton, Norman H. Rogers
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Abstract
Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
Claims12
A pharmaceutical composition for the treatment of bacterial infections comprising an antibacterially effective amount of a compound of the formula:
- ##STR31## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo, in combination with a pharmaceutical carrier.
A pharmaceutical composition according to claim 30 wherein in said compound R is 2-oxo-4H-chromen-4-yl, 2-oxo-4-methyl-2H-chromen-7-yl, 2-methyl-4-oxo-4H-chromen-7-yl, 2-phenyl-4-oxo-4H-chromen-7-yl, 2-oxo-4-carbethoxy-2H-chromen-7-yl, 2-carbethoxy-4-oxo-4H-chromen-7-yl, quinol-8-yl, 2-pyridyl, 3-pyridyl, or 4-pyridyl.
The method of treating bacterial infections in humans and other animals which comprises administering to a human or other animal in need thereof an antibacterially effective amount of a compound of the formula:
- ##STR32## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo.
Dependencies are inferred from the claim text.