Immunoregulatory diketopiperazine compounds
AssigneeOrtho Pharmaceutical Corporation
InventorsGeorge Heavner, Foe-Siong Tjoeng, Gideon Goldstein
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Abstract
Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.
Claims7
A chemical compound of formula:
- ##STR12## and optical isomers and pharmaceutically acceptable acid m is 1 and n is addition salts thereof, wherein m is 1 or 2 and n is 3 or 4.
A chemical compound selected from the group consisting of cyclo-(GLN-ORN), cyclo-(ASN-LYS), cyclo-(ASN-ORN), and pharmaceutically acceptable acid addition salts thereof.
A chemical compound selected from the group consisting of cyclo-(D-GLN-LYS), cyclo-(D-GLN-D-ORN), cyclo-(D-ASN-D-LYS), cyclo-(D-ASN-D-ORN), and the pharmaceutically acceptable acid addition salts thereof.
An immunoregulatory pharmaceutical composition comprising, in admixture with a pharmaceutically acceptable vehicle, an effective immunoregulatory amount of a compound of formula:
- ##STR13## or an optical isomer or pharmaceutically acceptable acid addition salt thereof, where m is 1 or 2 and n is 3 or 4.
A method of regulating the immune system in a subject in need of same, which comprises administering to said subject an effective immunoregulatory amount of a compound of formula:
- ##STR14## or an optical isomer or pharmaceutically acceptable acid addition salt thereof, wherein m is 1 or 2 and n is 3 or 4.
Dependencies are inferred from the claim text.