Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof

Abstract

Improved delivery and absorption of erythromycin in warm-blooded animals is achieved by administering thereto a non-toxic pharmaceutical effervescent enteric-coated tablet comprising: (a) an antibiotic effective amount of a non-toxic pharmaceutically acceptable soluble form of erythromycin; (b) a non-toxic pharmaceutically acceptable inert diluent; and (c) a non-toxic pharmaceutically acceptable effervescent couple acid and base; and (d) a non-toxic pharmaceutically acceptable enteric coating maintained over the tableted mixture of (a), (b), and (c) above. The subject composition is extremely useful in the treatment of bacterial infections in warm-blooded animals, particularly in the mitigation and treatment of upper and lower respiratory tract, skin and soft tissue infections of mild to moderate severity.

Dependencies are inferred from the claim text.