Nitrogen heterocycles
AssigneeBurroughs Wellcome Co.
InventorsAlbert G. Caldwell, Norman Whittaker
Life of this patent
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Abstract
1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.
Claims7
A compound of formula (II) ##STR6## wherein J is alkyl of 1 to 6 carbon atoms, J.sup.3 is hydrogen or benzyloxycarbonyl, Z is hydrogen or alkyl, one of Z.sup.1 and Z.sup.2 is represented by the group --CH.sub.2 --X--X.sup.1 --X.sup.2 wherein X is --CH.sub.2 --CQ.sub.2 -- in which each Q is independently selected from hydrogen and alkyl or the two Q'S together form alkylene having from four to six carbon atoms;
- X.sup.1 is a covalent bond or a straight or branched alkylene chain having 1 to 6 carbon atoms;
- X.sup.2 is selected from carboxyl or alkoxycarbonyl;
- the other of Z.sup.1 and Z.sup.2 is represented by the group --Y--Y.sup.1 --Y.sup.2 --Y.sup.3, wherein Y is --CR.sub.2 --CH.sub.2 -- in which each R is independently selected from hydrogen and methyl;
- Y.sup.1 is methylene, methylene substituted by hydroxyl or methylene substituted by hydroxyl and alkyl;
- Y.sup.2 is a covalent bond or straight or branched alkylene having 1 to 7 carbon atoms optionally substituted on the carbon adjacent Y.sup.1 by one or two groups each of which is alkyl;
- Y.sup.3 is hydrogen
- or a salt thereof wherein the term alkyl as it appears above has one to six carbon atoms.
The compound ethyl 2-(N-(benzyloxycarbonylglycyl)-N-6-ethoxycarbonylhexyl amino)decanoate.
The compound ethyl 2-(N-glycyl-N-6-ethoxycarbonylhexyl)amino)decanoate.
The compound diethyl 2-(N-benzyloxycarbonylglycyl-N-(3-hydroxyoctyl)amino) nonanedioate.
The compound diethyl 2-(N-glycyl-N-(3-hydroxyoctyl)amino)nonanedioate.
The compound diethyl 2-(N-benzyloxycarbonylglycyl-N-octyl)amino)nonanedioate.
The compound diethyl 2-(N-glycyl-N-octyl)amino)nonanedioate.
Dependencies are inferred from the claim text.