Selecting perfluorocarbon compounds for synthetic blood
AssigneesChildren's Hospital Medical Center, Suntech, Inc.
InventorsLeland C. Clark, Jr., Robert E. Moore
Life of this patent
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Abstract
A process for selecting a perfluorocarbon compound from those having about 9 to 12 carbon atoms for preparing synthetic blood compositions. The process involves determining the critical solution temperature of the perfluorocarbon compound in a solvent such as n-hexane. The perfluorocarbon compound is accepted as suitable for preparing a synthetic blood composition if its critical solution temperature falls below a selected temperature set by the number of carbon atoms in the perfluorocarbon compound.
Claims5
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising:
- (a) dissolving a candidate perfluorocarbon compound in a solvent;
- (b) determining the critical solution temperature of said candidate perfluorocarbon;
- and
- (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than;
- (1) a first temperature when the perfluorocarbon has nine carbon atoms;
- (2) a second temperature when the perfluorocarbon has ten carbon atoms;
- (3) a third temperature when the perfluorocarbon has eleven carbon atoms;
- (4) a fourth temperature when the perfluorocarbon has twelve atoms;
- and
- whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising:
- (a) dissolving a candidate perfluorocarbon compound in n-hexane;
- (b) determining the critical solution temperature of said candidate perfluorocarbon;
- and
- (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than:
- (1) 20.degree. C. when the perfluorocarbon has nine carbon atoms;
- (2) 30.degree. C. when the perfluorocarbon has ten carbon atoms;
- (3) 35.degree. C. when the perfluorocarbon has eleven carbon atoms;
- (4) 45.degree. C. when the perfluorocarbon has twelve carbon atoms;
- and
- whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
Dependencies are inferred from the claim text.