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US 4,288,624 AGranted
Acylation or sulfenylation process
AssigneeEli Lilly and Company
InventorsRiaz F. Abdulla, Lawrence A. Morgan
Life of this patent
Estimating the term…
Abstract
A process or acylating or sulfenylating 1-amino-2-phenyl-1-butene-3-ones to prepare the corresponding 4-acyl or 4-substituted-thio compounds provides intermediates useful for preparing herbicides.
Claims21
A process for preparing a compound of the formula ##STR11## wherein R is chloro, bromo, fluoro or trifluoromethyl;
- R.sup.1 and R.sup.2 are independently C.sub.1 -C.sub.3 alkyl, or R.sup.1 and R.sup.2 combine with the nitrogen atom to which they are attached to form pyrrolidino, piperidino, morpholino or N-methylpiperazino;
- R.sup.3 is ##STR12## R.sup.4 is C.sub.1 -C.sub.4 alkyl, phenyl, C.sub.1 -C.sub.2 alkyl monosubstituted with methoxy, or phenyl monosubstituted with chloro, bromo, fluoro or trifluoromethyl;
- R.sup.5 is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 fluoroalkyl, phenyl, benzyl, or phenyl substituted with C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halo;
- which process comprises reacting an anion of the formula ##STR13## with a compound of the formula ##STR14## wherein X is chloro or bromo, in an inert organic solvent.
1 more element
Dependencies are inferred from the claim text.