Selective oxidation of 1,2-diphenyl-4-(2-phenylthio)ethyl)-3,5-pyrazolidinedione to the sulfinyl compound
AssigneeAmerican Home Products Corporation
InventorsGeorge A. Church, Chih H. Chou
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Abstract
Herein is described a process for oxidizing 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione with peroxymonosulfuric acid to obtain 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione.
Claims5
A process for preparing 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione, with only very small amounts of the undesired corresponding sulfone, which comprises oxidizing 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione with peroxymonosulfuric acid.
A process of preparing 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione, with only very small amounts of the undesired corresponding sulfone, which comprises oxidizing 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione with about 1.3 to 1.5 molar equivalents of peroxymonosulfuric acid, with respect to said 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione, in a solution of aqueous acetic acid at about 5.degree. to 25.degree. C.
Dependencies are inferred from the claim text.