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US 4,288,601 AGranted
Fluorination process
AssigneeMerck & Co., Inc.
InventorsJanos Kollonitsch, Stephen Marburg
Life of this patent
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Abstract
A process for preparing .alpha.-fluoromethyl amino acids is disclosed. The process utilizes SF.sub.4 and BF.sub.3 or AlCl.sub.3 in HF to effect the fluorination.
Claims8
A process for preparing compounds having the formula ##STR6## wherein R is ##STR7## which comprises reacting a compound having the formula ##STR8## with (a) SF.sub.4 and (b) BF.sub.3, in liquid HF at temperatures ranging from about -80.degree. C. to about 20.degree. C.
Dependencies are inferred from the claim text.