Process for producing pyridine derivatives having a trifluoromethyl group at .beta.-position thereof
AssigneeIshihara Sangyo Kaisha, Ltd.
InventorsRyuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Yasuhiro Tsujii, Shigeyuki Nishimura
Life of this patent
Estimating the term…
Abstract
Pyridine derivatives having a trifluoromethyl group at .beta.-position thereof are produced by reacting .beta.-picoline with chlorine and hydrogen fluoride in a vapor phase at high temperature for a short time. The reaction condition can be mild and the yield of the object compound is increased by reacting them in the presence of a specific metal fluodie. The pyridine derivatives useful as starting materials for agricultural chemicals and medicines can be continuously obtained by a simple reaction at high yield.
Claims17
A process for producing a pyridine derivative having a trifluoromethyl group at the .beta.-position thereof and having the formula:
- ##STR2## wherein X and Y, respectively, are hydrogen or chloro which comprises reacting .beta.-picoline with chlorine and hydrogen fluoride by a vapor phase reaction in the absence of a catalyst.
A process for producing a pyridine derivative having a trifluoromethyl group at the .beta.-position thereof and having the formula:
- ##STR3## wherein X and Y, respectively, are hydrogen or chloro which comprises reacting .beta.-picoline with chlorine and hydrogen fluoride by a vapor phase reaction in the presence of a catalyst comprising a fluoride of a metal selected from the group consisting of aluminum, chromium, iron, nickel, cobalt, manganese, chromium with aluminum, iron with aluminum, manganese with aluminum, and cobalt with aluminum.
Dependencies are inferred from the claim text.