1,2-Diacylamino-1,2-di(4-pyridyl)ethanes and process for producing thereof
AssigneeLaboratorios Made, S.A.
InventorsMiguel F. Brana, Maria L. Lopez Rodriguez, Jose M. Castellano Berlanga, Jose L. Soto Camara, Cristobal Martinez Roldan
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Abstract
1,2-diacylamino-1,2-di(4-pyridil)ethanes of general formula: ##STR1## where R is a saturated or unsaturated alkyl group, a homocyclic or heterocyclic aromatic ring, with or without substituents, or a saturated or unsaturated cycloalkyl. Said compounds are useful as analgesic. A process for preparing such products is also described.
Claims22
A compound of the formula ##STR6## where R is an alkyl group of 1 to 7 carbon atoms;
- a phenyl group which may be substituted with an alkyl group of 1 to 4 carbon atoms, halogen, trifluromethyl, methoxy, methylsulfonyl or nitro;
- benzyl or diphenyl.
A process for the production of a 1,2-diacylamino-1,2-di(4-pyridyl)ethane of formula ##STR7## where R is an alkyl group of 1 to 7 carbon atoms;
- a phenyl group which may be substituted with an alkyl group of 1 to 4 carbon atoms, halogen, trifluromethyl, methoxy, methylsulfonyl or nitro;
- benzyl or diphenyl, which comprises reacting an N-(4-picolyl) amide or preferably its N-oxide of the formula ##STR8## where R has the aforementioned meaning, with acid halides or acid anhydrides at temperatures above 110.degree. C., with or without solvent, between 1 and 24 hours, the product precipitating within reaction and them being filtered and purified by crystallization in the usual manner.
Dependencies are inferred from the claim text.