4-Substituted 2-iminoimidazolidine compounds
AssigneeA. H. Robins Company, Incorporated
InventorAlbert D. Cale, Jr.
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Abstract
This invention provides a novel class of 2-iminoimidazolidines which include 4-substituted derivatives such as 4-(2-chloroethyl)-1-methyl-2-methylimino-3-phenyl imidazolidine fumarate: ##STR1## This illustrated 4-substituted 2-iminoimidazolidine compound exhibits cardiovascular hypotensive, hypoglycemic (glucose tolerance, and sugar cataract) and anti-inflammatory (pleural effusion) pharmacological activities in test animals.
Claims11
A 2-iminoimidazolidine compound corresponding to the formula:
- ##STR35## wherein R is loweralkyl;
- R.sup.1 is a member selected from hydrogen, loweralkyl, phenyl, loweralkylphenyl, and chlorophenyl;
- R.sup.2 is a member selected from loweralkyl, phenyl, loweralkylphenyl and chlorophenyl;
- X is a member selected from amino, diloweralkylamino, di(phenylloweralkyl)amino, 1-piperidino, 1-piperazino, and 1-morpholino;
- and n is the integer 1 or 2, or a pharmaceutically acceptable acid addition salt thereof.
A compound which is 4-[2-(3-ene-4-phenyl-1-piperidino)ethyl]-1-ethyl-2-imino-3-phenylimidazoli dine or a pharmaceutically acceptable acid addition salt thereof.
A compound which is 1-ethyl-2-imino-4-[2-(4-methyl-1-piperazino)ethyl]-3-phenylimidazolidine or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.