Method of producing the A-30912 antibiotics
AssigneeEli Lilly and Company
InventorsLaVerne D. Boeck, Ralph E. Kastner
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Abstract
The microorganism Aspergillus nidulans var. roseus NRRL 11440 and the method of producing the A-30912 antibiotics by submerged aerobic fermentation of this microorganism to give the A-42355 antibiotic complex. A-30912 factors A, B, D, and H are separated from the A-42355 complex by chromatography. The A-42355 complex and A-30912 factors A, B, D, and H are antifungal agents.
Claims7
The method of producing the A-42355 antibiotic complex comprising A-30912 factors A, B, D, and H which comprises cultivating Aspergillus nidulans var. roseus NRRL 11440 in a culture medium containing assimilable sources of carbohydrate, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
A biologically pure culture of the microorganism Aspergillus nidulans var. roseus NRRL 11440 said culture being capable of producing the A-42355 antibiotic complex comprising A-30912 factors A,B,D and H.
Dependencies are inferred from the claim text.