Ethynylbenzene compounds and derivatives thereof
AssigneeWilliam H. Rorer, Inc.
InventorJulius Diamond
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Abstract
Novel ethynylbenzene compounds and derivatives are described. Their use in the treatment of inflammation is also disclosed.
Claims12
A method for treating inflammation, pain or fever comprising administering to a patient suffering from said inflammation, pain or fever a therapeutically effective amount between 0.5 to 100 mg/kg of body weight per day of at least one compound of the formula:
- ##STR8## wherein R is selected from the group consisting of lower alkyl of 1 to 7 carbon atoms,
- cycloalkyl of 5 to 7 carbon atoms,
- - 7carbon atoms alkyl substituted cycloalkyl of 5 to 7 carbon atoms,
- cycloalkenyl of 5 to 7 carbon atoms, and
- 1-to 7 carbon atoms alkyl substituted phenyl.
A method of treating inflammation, fever or pain in a warm blooded animal which comprises administering to the animal an effective amount of an agent which is (4-(2-fluoro-phenyl)phenyl) acetylene.
A method of treating inflammation, fever or pain in a warm blooded animal which comprises administering to the animal an effective amount of an agent which is (3-fluoro-4-phenylphenyl) acetylene.
A pharmaceutical preparation in a dosage unit form adapted for oral administration to obtain an anti-inflammatory, anti-pyretic, or analgesic effect, comprising, per dosage unit, an effective non-toxic amount of an active agent, and a pharmaceutical diluent, said active agent being either (4-(2-fluorophenyl)phenyl) acetylene or (3-fluoro-4-phenylphenyl) acetylene.
Dependencies are inferred from the claim text.