Derivatives of arylalkanoic acids, compositions and use
AssigneeScience Union et Cie
InventorsMichel Vincent, Jacques Duhault, Michelle Boullanger, Georges Remond
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Abstract
There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD.sub.50 greater than 800 mg/kg, intraperitoneally, in male mice. A method of use, compositions, and a process for synthesis are also described.
Claims12
The (Aryl alkyl) alkanoic acids of the formula ##STR15## including the diastereoisomers and enantiomers thereof, wherein Z is oxygen or sulphur;
- lower-alkyl is 1 to 5 carbon atoms, inclusive;
- Y is halogen, trifluoromethyl, or lower-alkyl;
- m' is zero or number from one to three, inclusive;
- and X is hydroxy, or the grouping OM in which M is the monovalent cation of a mineral base.
Dependencies are inferred from the claim text.