Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions
AssigneeA. H. Robins Company, Incorporated
InventorAlbert D. Cale, Jr.
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Abstract
This invention provides a novel class of 2-iminoimidazolidines which include 4-substituted derivatives such as 4-(2-chloroethyl)-1-methyl-2-methylimino-3-phenyl imidazolidine fumarate: ##STR1## This illustrated 4-substituted 2-iminoimidazolidine compound exhibits cardiovascular hypotensive, hypoglycemic (glucose tolerance, and sugar cataract) and anti-inflammatory (pleural effusion) pharmacological activities in test animals.
Claims4
A pharmaceutical composition for the treatment of hyperglycemia comprising a pharmaceutical carrier and a hyperglycemia inhibiting quantity of a 2-iminoimidazolidine compound corresponding to the formula:
- ##STR35## wherein R is loweralkyl;
- R.sup.1 is a member selected from hydrogen, loweralkyl, phenyl, loweralkylphenyl, and chlorophenyl;
- R.sup.2 is a member selected from loweralkyl, phenyl, loweralkylphenyl and chlorophenyl;
- X is member selected from amino, diloweralkylamino, di(phenylloweralkyl) amino, 1-piperidino, 1-piperazino, 1-morpholino, and chloro;
- and n is the integer 1 or 2, or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.