3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutical antibacterial compositions containing them
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakashi Kamiya, Kunihiko Tanaka, Tsutomu Teraji, Yoshiharu Nakai
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Abstract
The present invention relates to new 3,7 disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities and to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in human being and animals.
Claims30
3,7-Disubstituted-3-cephem-4-carboxylic acid compounds of the formula:
- ##STR12## wherein R.sup.1 is amino or an amino group protected by an eliminatable protective group;
- R.sup.2 is --CONH--R.sup.5, ##STR13## or --NHCO--R.sup.7 ;
- R.sup.3 is carboxy or a carboxy group protected by an eliminatable protective group;
- R.sup.4 is C.sub.1 -C.sub.6 alkanoyloxy, benzothiazolythio, tetrazolylthio, or thiadiazolylthio, the latter two of which may have one C.sub.1 -C.sub.6 alkyl;
- R.sup.5 is pyridyl, thiazolyl, or phenyl having one or more substituent(s) selected from halogen, hydroxy, carboxy and C.sub.2 -C.sub.7 alkoxycarbonyl;
- R.sup.6 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.7 is isoxazolyl disubstituted with C.sub.1 -C.sub.6 alkyl and halogen substituted phenyl, or phenyl having one or more substituent(s) selected from hydroxy and halogen;
- and
- A is C.sub.1 -C.sub.6 alkylene;
- and
- pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.