Generator for ionic gallium-68 based on column chromatography
AssigneeMassachusetts Institute of Technology
InventorsRudi D. Neirinckx, Michael A. Davis
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Abstract
A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing .sup.68 Ga-fluorides. The solution then is neutralized prior to administration.
Claims5
The process for obtaining a physiologically acceptable aqueous solution of gallium-68 which comprises binding .sup.68 GeF.sub.6 =to an anion-exchange resin from a hydrofluoric acid solution whereby gallium-68 fluorides are formed in situ from said .sup.68 GeF.sub.6 =, eluting said gallium-68 fluorides from said resin with an aqueous HF solution and neutralizing the aqueous HF solution containing gallium-68 fluorides.
A kit for the preparation of a physiologically acceptable solution of gallium-68 from a resin column containing bound germanium 68 which comprises a first container having a volume of about 2 to 4 ml in which is aseptically and hermetically sealed a 0.005N to 0.01N HF solution and a second container having a volume of about 4 to 10 ml and in which is sealed a neutralizing agent for said acidic solution.
A generator for gallium-68 fluorides which comprises a column of an anion-exchange resin containing .sup.68 GeF.sub.6 =bound to said resin.
Dependencies are inferred from the claim text.