Back to results
US 4,287,355 AGranted
Carboxyl-(phenyl or tolyl)-sulfonium salts
AssigneeSandoz Ltd.
InventorFaizulla G. Kathawala
Life of this patent
Estimating the term…
Abstract
Carbalkoxy-phenyl (or tolyl)-dialkyl-or alkyl-phenyl-sulfonium salts, e.g. p-(.alpha.-carbethoxy) tolyl-n-octadecyl-phenyl sulfonium tetrafluoroborate, are useful as pharmaceuticals. The compounds are obtainable by reaction of a carbalkoxy-phenyl (or-tolyl)-dialkyl-or-alkyl-phenyl-sulfide with an alkylhalide in the presence of a metal salt, e.g. silver tetrafluoroborate.
Claims27
A compound of the formula:
- ##STR8## wherein R.sup.1 is alkyl having from 8 to 24 carbon atoms;
- R.sup.2 is alkyl having from 1 to 6 carbon atoms or unsubstituted or substituted phenyl of the formula:
- ##STR9## wherein Y is a hydrogen atom, halo having an atomic weight of from about 19 to 80, alkyl of from 1 to 4 carbon atoms, or alkoxy of from 1 to 4 carbon atoms;
- R.sup.3 is a hydrogen atom, halo having an atomic weight of from about 19 to 80, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms;
- R.sup.4 is a hydrogen atom, or alkyl having from 1 to 6 carbon atoms;
- n is 0 or 1;
- and
- Z.sup..crclbar. is an anion forming a pharmaceutically acceptable non-toxic salt of the corresponding cation;
- provided that R.sup.4 is alkyl when R.sup.2 is other than alkyl.
6 more elements
Dependencies are inferred from the claim text.