Preparation of sulphoalkyl quaternary salts
AssigneeCiba-Geigy Corporation
InventorsRainer Kitzing, Geoffrey E. Ficken, Victor W. Dolden
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Abstract
Sulphoalkyl quaternary salts of the formula ##STR1## wherein X is --O--, --Se--, --S--, --NR-- or --CR(R)--, R is hydrogen or alkyl, R.sub.1 is hydrogen, methyl or ethyl, R.sub.2 and R.sub.3 are each hydrogen or substituents or together represent the atoms necessary to complete an optionally substituted benzene ring, R.sub.4 is optionally substituted alkylene of 3 or 4 carbon atoms and n is 1 or 0, except that when n is 1, R.sub.1 cannot be hydrogen, are prepared by heating at a temperature above 80.degree. C. a heterocyclic base of the formula ##STR2## wherein X, R.sub.1, R.sub.2, R.sub.3 and n have the indicated meanings with a hydroxysulphonic acid of the formula HOR.sub.4 SO.sub.3 H.
Claims8
A process for the preparation of quaternary salts of the general formula ##STR7## wherein X is --O--, --Se--, --S--, --NR-- or --CR(R)--, wherein R is alkyl of 1 to 4 carbon atoms or hydrogen, R.sub.1 is hydrogen, methyl or ethyl, R.sub.2 and R.sub.3 are each hydrogen, alkyl or hydroxyalkyl of 1 to 4 carbon atoms, phenyl, halogen or halogenated alkyl or together they represent the atoms to complete a benzene ring which is unsubstituted or substituted by methyl, ethyl, trifluoromethyl, chlorine, bromine and or and R.sub.4 is an alkylene chain having 3 or 4 carbon atoms in the chain and n is 1 or 0, except that when n is 1, R.sub.1 cannot be hydrogen, which comprises heating at a temperature above 80.degree. C., a heterocyclic base of the general formula ##STR8## where X, R.sub.1, R.sub.2 and R.sub.3 and n have the indicated meanings with a hydroxysulphonic acid of the general formula
- HO--R.sub.4 --SO.sub.3 H
- where R.sub.4 has the indicated meaning under conditions so that the water formed is removed from the reacting mixture.
Dependencies are inferred from the claim text.