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US 4,287,346 AGranted
Cyanoguanidine derivatives
AssigneeEisai Co., Ltd.
InventorsSatoru Tanaka, Katsutoshi Shimada, Kazunori Hashimoto, Kiichi Ema, Koichiro Udea
Life of this patent
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Abstract
Novel cyanoguanidine derivatives, and acid addition salts thereof useful as medicines which have pharmacological actions such as anti-secretory effect, local anesthesia action and the like; and process for the preparation thereof.
Claims12
A cyanoguanidine derivative of the formula:
- ##STR54## wherein A represents phenyl;
- phenyl substituted by lower alkyl, lower alkenyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfonyl or halo lower alkyl;
- furyl;
- thienyl or cycloalkyl of 5 to 6 carbon atoms;
- B represents pyridyl or pyridine-N-oxide;
- R represents lower alkyl or lower alkenyl;
- X represents lower alkylene or lower alkylene having a terminal sulfur atom;
- and
- p is 0 or 1, with the proviso that (i) when A is unsubstituted phenyl, B is pyridine-N-oxide and (ii) when A is unsubstituted phenyl and B is pyridine-N-oxide, p is 0, or a pharmaceutically acceptable acid addition salt thereof.
6 more elements
Dependencies are inferred from the claim text.