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US 4,287,302 AGranted
Microbiological modification of antibiotic A23187 esters
AssigneeEli Lilly and Company
InventorsBernard J. Abbott, David S. Fukuda
Life of this patent
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Abstract
Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.
Claims5
A process for preparing a compound of the formula:
- ##STR5## wherein R is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, or t-butyl;
- which comprises cultivating Streptomyces chartreusis NRRL 11407 in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic conditions;
- adding a (lower) alkyl ester of antibiotic A23187 to the culture medium;
- and incubating the culture medium until a substantial amount of the compound is produced.
1 more element
Dependencies are inferred from the claim text.