US 4,287,221 A · Method for providing enteric coating on solid dosage forms

Abstract

The invention provides a novel method for providing entric coating on solid dosage forms using an aqueous coating liquid so that the problems inherent to the use of a coating liquid in an organic solvent can completely be eliminated. The inventive method comprises dispersing a finely divided powder of a hydroxypropylmethylcellulose phthalate in an aqueous medium containing triacetin to give an aqueous coating liquid with which the solid dosage forms are coated, for example, by spraying and dried. It is necessary that the preparation of the coating liquid and the coating procedure with the coating liquid are performed throughout while keeping the temperature of the liquid below 25.degree. C. so as that the particles of the hydroxypropylmethylcellulose phthalate are not dissolved in the medium forming a stable dispersion without adhesive coalescence.

Claims4

Dependent claims

A method for providing an enteric coating on a solid dosage from which comprises

(a) dispersing a hydroxpropylmethylcellulose phtalate having an average particle diameter not exceeding 100 .mu.m in water containing triacetin amount from 5% to 50% by weight based on the amount of the hydroxypropylmethylcellulose phthalate at a temperature of 25.degree. C. or below to form an aqueous coating liquid,
(b) spraying the thus prepared coating liquid on to the surface of the solid dosage form while the coating liquid is kept at a temperature of 25.degree. C. or below to form a coating layer thereon, and
(c) drying the thus coated solid dosage form.

Dependencies are inferred from the claim text.

Method for providing enteric coating on solid dosage forms

Life of this patent

Method for providing enteric coating on solid dosage forms

Life of this patent

Abstract

Claims4