US 4,287,214 A · Dithranol compositions stabilized with alpha hydroxyacids

Abstract

Chemically stable dithranol compositions useful as topical treatment for inflammatory disorders such as psoriasis, eczema and seborrheic dermatitis are disclosed. Incorporation of a certain alpha hydroxyacid as its free acid, lactone, amide or salt form in dithranol containing compositions has been found to chemically stabilize said compositions. The alpha hydroxyacids include glyceric acid, gluconic acid, galacturonic acid, glucuronic acid, glucoheptonic acid, galactonic acid, malic acid, mucic acid, citric acid, saccharic acid, tartaric acid, tartronic acid, isocitric acid and glucuronamide. A single member of the above alpha hydroxyacids may be present in a total amount of from 0.01 to 1 percent by weight of the total composition, or a plurality thereof may be present in a preferred concentration range of from 0.02 to 0.5 percent by weight of the total composition.

Claims24

Dependent claims

In a composition containing a anti-inflammatory effective amount of dithranol in a pharmaceutically acceptable vehicle for topical application, the improvement comprising:

a stabilizing effective amount of at least one member selected from the group consisting of:
a glyceric acid or a derivative thereof having the formula
R(CR.sub.1 OH).sub.n COOH
wherein
n=2,3,4,5,6, or 7 and
R,R.sub.1 =H, CHO, or alkyl having from 1 to 7 carbon atoms, or the lactone or amide thereof;
and an alpha hydroxy polycarboxylic or a derivative thereof having the formula
(CRX).sub.m (COOH).sub.n
wherein
m=1,2,3,4,5, or 6
n=2,3,4 and
X=OH or H when m.gtoreq.2 and with one or more than one OH group present.
R=H, CHO, or alkyl having from 1 to 7 carbon atoms, or the lactone, amide or salt thereof.

10 more elements

Dependencies are inferred from the claim text.

Dithranol compositions stabilized with alpha hydroxyacids

Life of this patent

Dithranol compositions stabilized with alpha hydroxyacids

Life of this patent

Abstract

Claims24