Pharmaceutical composition containing 1,3,5-substituted biuret compound

A method of treating a patient having a pyretic or inflammatory condition, said method comprising administering to said patient a therapeutically effective amount of a compound of the formula:

• ##STR81## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a substituted lower alkyl group having chlorine atom(s), cyano group(s), dimethylamino group(s), hydroxy group(s), methoxy group(s) or carboxy group(s) as the substituents, a lower alkenyl group, a hydroxy group, a methoxy group, an acetyl group or a phenyl group;
• R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group;
• R.sup.3 is a phenyl group or a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methyoxy group(s), methylenedioxy group(s), hydroxy group(s), dimethylamino group(s), carboxyl group(s) or carboxymethyl group(s) as the substituents(s), or a benzyl group.

An analgesic, anti-inflammatory or anti-pyretic composition in the form of a tablet, capsule, granules, pouder, injection preparation, suppository preparation, topical oinment or cream or peroral sysup, elixir or oily suspension containing as the active ingredient an effective amount of a 1,3,5-substituted biuret compound of the formula (1) ##STR82## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a substituted lower alkyl group having chlorine atom(s), cyano group(s), dimethylamino group(s), hydroxy group(s), methoxy group(s) or carboxy group(s) as the substituents, a lower alkenyl group, a hydroxy group, a methoxy group, an acetyl group or a phenyl group;

• R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group;
• R.sup.3 is a phenyl group or a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), methylenedioxy group(s), hydroxy group(s), dimethylamino group(s), carboxyl group(s) or carboxymethyl group(s) as the substituents, with a pharmaceutically acceptable carrier.