Hypotensive and analgesic compounds and compositions and methods for using same

Abstract

Novel cyclic acetals of the general formulae: ##STR1## wherein R.sub.1 is ##STR2## wherein R.sub.2 is hydrogen, alkyl, aryl or R.sub.1, wherein R.sub.3 through R.sub.10 are hydrogen, alkyl or aryl, wherein R.sub.5 and R.sub.6 together may form .dbd.O, wherein X is hydrogen, alkyl, cycloalkyl, aryl, hydroxyaryl or arylakyl, or wherein R.sub.8 is ##STR3## are described. Said compounds are prepared by mixing approximately equimolar amounts of the appropriate aldehyde or ketone, and enediol compound, and allowing same to react in aqueous solution under a nitrogen atmosphere. Compositions containing these novel compounds exhibit hypotensive and analgesic properties and are useful in the treatment of hypertension and pain in animals and humans.

Dependencies are inferred from the claim text.