Anovulatory method and chicken feed compositions
AssigneeMerck & Co., Inc.
InventorsGeorge Olson, Richard L. Tolman, Roger M. Weppelman
Life of this patent
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Abstract
2-(Substituted phenylimino)imidazolidines delay the onset of egg production in young pullets and inerrupt egg production in mature hens and are useful in producing an artificial molt.
Claims18
An anovulatory composition comprising a solid poultry feedstuff having intimately dispersed therein at least an effective anovulatory amount of a compound of structural formula:
- ##STR14## or a non-toxic salt thereof, wherein:
- R is
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) bromo, or
- (5) iodo;
- R.sup.1 and R.sup.2 are independently
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) fluoro,
- (5) bromo,
- (6) iodo,
- (7) hydrogen,
- (8) nitro,
- (9) amino,
- (10) C.sub.1-3 alkylamino,
- (11) di(C.sub.1-3 alkyl)amino,
- (12) hydroxy,
- (13) carboxy,
- (14) C.sub.1-3 alkoxycarbonyl,
- (15) C.sub.1-4 alkanoyl,
- (16) C.sub.1-4 alkylthio,
- (17) trifluoromethylthio,
- (18) phenylthio,
- (19) C.sub.1-3 alkylphenylthio
- (20) C.sub.1-3 alkoxyphenylthio
- (21) chlorophenylthio,
- (22) bromophenylthio,
- (23) phenoxy,
- (24) C.sub.1-3 alkylphenoxy,
- (25) C.sub.1-3 alkoxyphenoxy,
- (26) chlorophenoxy,
- (27) bromophenoxy,
- (28) amino-C.sub.1-4 alkyl,
- (29) C.sub.1-3 alkylamino-C.sub.1-4 alkyl,
- (30) di(C.sub.1-3 alkyl)amino-C.sub.1-4 alkyl,
- (31) hydroxy C.sub.1-4 alkyl, or
- (32) C.sub.1-3 alkoxy-C.sub.1-4 alkyl.
A poultry feed premix composition comprising a solid poultry feedstuff having intimately dispersed therein an anovulatory compound in sufficient amount so that after dilution to final poultry feed said feed contains an effective amount of the anovulatory compound of structural formula:
- ##STR15## or a non-toxic salt thereof, wherein:
- R is
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) bromo, or
- (5) iodo;
- R.sup.1 and R.sup.2 are independently
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) fluoro,
- (5) bromo,
- (6) iodo,
- (7) hydrogen,
- (8) nitro,
- (9) amino,
- (10) C.sub.1-3 alkylamino,
- (11) di(C.sub.1-3 alkyl)amino,
- (12) hydroxy,
- (13) carboxy,
- (14) C.sub.1-3 alkoxycarbonyl,
- (15) C.sub.1-4 alkanoyl,
- (16) C.sub.1-4 alkylthio,
- (17) trifluoromethylthio,
- (18) phenylthio,
- (19) C.sub.1-3 alkylphenylthio
- (20) C.sub.1-3 alkoxyphenylthio
- (21) chlorophenylthio,
- (22) bromophenylthio,
- (23) phenoxy,
- (24) C.sub.1-3 alkylphenoxy,
- (25) C.sub.1-3 alkoxyphenoxy,
- (26) chlorophenoxy,
- (27) bromophenoxy,
- (28) amino-C.sub.1-4 alkyl,
- (29) C.sub.1-3 alkylamino-C.sub.1-4 alkyl,
- (30) di(C.sub.1-3 alkyl)amino-C.sub.1-4 alkyl,
- (31) hydroxy C.sub.1-4 alkyl, or
- (32) C.sub.1-3 alkoxy-C.sub.1-4 alkyl.
A method of arresting ovulation in poultry which comprises the administration to the poultry of an effective amount of an anovulatory compound of formula:
- ##STR16## or a non-toxic salt thereof, wherein:
- R is
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) bromo, or
- (5) iodo;
- R.sup.1 and R.sup.2 are independently
- (1) C.sub.1-4 alkyl,
- (2) C.sub.2-5 alkenyl,
- (3) chloro,
- (4) fluoro,
- (5) bromo,
- (6) iodo,
- (7) hydrogen,
- (8) nitro,
- (9) amino,
- (10) C.sub.1-3 alkylamino,
- (11) di(C.sub.1-3 alkyl)amino,
- (12) hydroxy,
- (13) carboxy,
- (14) C.sub.1-3 alkoxycarbonyl,
- (15) C.sub.1-4 alkanoyl,
- (16) C.sub.1-4 alkylthio,
- (17) trifluoromethylthio,
- (18) phenylthio,
- (19) C.sub.1-3 alkylphenylthio,
- (20) C.sub.1-3 alkoxyphenylthio,
- (21) chlorophenylthio,
- (22) bromophenylthio,
- (23) phenoxy,
- (24) C.sub.1-3 alkylphenoxy,
- (25) C.sub.1-3 alkoxyphenoxy,
- (26) chlorophenoxy,
- (27) bromophenoxy,
- (28) amino-C.sub.1-4 alkyl,
- (29) C.sub.1-3 alkylamino-C.sub.1-4 alkyl,
- (30) di(C.sub.1-3 alkyl)amino-C.sub.1-4 alkyl,
- (31) hydroxy C.sub.1-4 alkyl, or
- (32) C.sub.1-3 alkoxy-C.sub.1-4 alkyl.
Dependencies are inferred from the claim text.