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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsEdit Kosa, Janos Borvendeg, Zsuzsanna Huszti, Judit Kosary, Geza Szilagyi, Laszlo Tardos, Endre Kasztreiner, Laszlo Nagy, Erzsebet Szuucs, Gabriella Kiss
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A pharmaceutical compositions with hypotensive effects which comprise a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof, ##STR1## wherein R.sup.1 is formula (II) ##STR2## wherein R.sup.4 and R.sup.5 each represent hydrogen, hydroxy, nitro at the same time R.sup.2 and R.sup.3 are hydrogen, or R.sup.1 are 3-chloro-6-pyridazinylamino, 3-methyl-6-pyridazinylamino or 3-carbamoyl-6-pyridazinylamino, and at the same time R.sup.2 and R.sup.3 form together formula (III), ##STR3## wherein R.sup.6 is C.sub.1-4 alkyl group, R.sup.7 is hydrogen or a C.sub.1-4 alkyl group, and n is an integer of 1 to 3, or R.sup.2 and R.sup.3 form together a group of the general formula (IV), =Q-R.sup.8 (IV) wherein Q is C.sub.5-7 cycloaliphatic, and R.sup.8 is hydrogen, a C.sub.1-4 alkoxycarbonyl or a C.sub.2-4 alkyl, and a compound of formula (V) or a pharmaceutically acceptable acid addition salt thereof, ##STR4## wherein R.sup.9 is naphthyl, 4-indolyl or 4-morpholino-1,2,5-thiadiazol-3-yl group or ##STR5## .
A pharmaceutical composition with increased hypotensive effect, comprising a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof, ##STR11## wherein R.sup.1 is a group of formula (II), ##STR12## wherein R.sup.4 and R.sup.5 each are hydrogen, hydroxy, nitro or C.sub.1-4 alkoxycarbonyl, and at the same time
A pharmaceutical composition with hypotensive effect, comprising a compound of the formula I or a pharmaceutically acceptable salt thereof ##STR16## wherein R.sup.4 is nitro or C.sub.1 to C.sub.4 alkoxycarbonyl and a .beta. receptor blocking compound of the formula V or a pharmaceutically acceptable salt thereof ##STR17## wherein R.sup.9 is naphthyl, 4-indolyl, 2,5-dichlorophenyl, 4-(2-methoxy-ethyl)-phenyl, 4-aminocarbonylmethyl-phenyl or 2-alkenyloxy-phenyl where the alkenyl group has 2 to 4 carbon atoms;
A pharmaceutical composition with hypotensive effect, comprising a compound of the formula I or a pharmaceutically acceptable salt thereof ##STR18## wherein R.sup.1 is 3-chloro-6-pyridazinyl-amino, 3-methyl-6-pyridazinyl-amino, or 3-carbamoyl-6-pyridazinyl-amino;
A pharmaceutical composition with hypotensive effect, comprising a compound of the formula I or a pharmaceutically acceptable salt thereof ##STR20## wherein R.sup.8 is 1-carbethoxy or 2,2-dimethyl and a .beta. receptor blocking compound of the formula V or a pharmaceutically acceptable salt thereof ##STR21## wherein R.sup.9 is naphthyl, 4-indolyl, 2,5-dichlorophenyl, 4-(2-methoxy-ethyl)-phenyl, 4-aminocarbonylmethyl-phenyl or 2-alkenyloxy-phenyl where the alkenyl group has 2 to 4 carbon atoms;
Dependencies are inferred from the claim text.