Purine derivatives
AssigneeBurroughs Wellcome Co.
InventorHoward J. Schaeffer
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Abstract
9-(2-Hydroxyethoxymethyl) (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharamceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-Hydroxyethoxymethyl)guanine and 2-amino-9-(2-hydroxyethoxymethyl) adenine are examples of especially active compounds of this invention. Also preferred because of its high oral absorption is the phosphate and especially the monophosphate of 9-(2-hydroxyethoxymethyl)guanine as well as pharmaceutically acceptable salts thereof.
Claims53
9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof.
9-(2-hydroxethoxymethyl) guanine monophosphate.
A compound of the formula ##STR14## where Z is a pharmaceutically acceptable cation and W is H or a a pharmaceutically acceptable cation.
A pharmaceutical composition comprising an effective non-toxic antiviral amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising an effective non-toxic antiviral amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate and a pharmaceutically acceptable carrier therefore.
A pharmaceutical composition comprising an effective nontoxic antiviral amount of a compound of the formula ##STR15## where Z is a pharmaceutically acceptable cation, and W is H or a pharmaceutically acceptable cation and a pharmaceutically acceptable carrier.
The method of treating a susceptible viral infection in a mammal which comprises the administration to said mammal of an effective, antiviral, non-toxic amount of 9-(2-hydroxyethoxymethyl)guanine monophosphate or a pharmaceutically acceptable salt thereof.
The method of treating herpes simplex or herpes zoster infection in mammals which comprises orally administering to said mammals in unit dosage form 0.1 to 250 mg/kg calculated as base of the 9-(2-hydroxyethoxymethyl)quanine monophosphate or a pharmaceutically acceptable salt thereof.
The method of treating a susceptable viral infection in a mammal which comprises the administration to said mammal of a compound of the formula ##STR16## where Z is a pharmaceutically acceptable cation and W is H or a pharmaceutically acceptable cation.
The method of treating a cytomegalovirus infection in a mammal which comprises administering an effective cytomegalovirus infection treatment amount of 9-(2-hydroxyethoxymethyl)guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating an adenovirus infection in a mammal which comprises administering an effective adenovirus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a rhino virus infection in a mammal which comprises administering an effective rhino virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a Mengo virus infection in a mammal which comprises administering an effective Mengo virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a Sindbis virus infection in a mammal which comprises administering an effective Sindbis virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a vaccinia virus infection in a mammal which comprises administering an effective vaccinia virus infection treatment ammount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a varicella virus infection in a mammal which comprises administering an effective varicella virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a herpes simplex virus infection in a mammal which comprises administering an effective herpes simplex virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
The method of treating a herpes zoster virus infection in a mammal which comprises administering an effective herpes zoster virus infection treatment amount of 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof to the infected mammal.
A pharmaceutical composition suitable for administration to the eye to treat a virus infection thereof which comprises an effective virus treatment amount of the compound 9-(2-hydroxyethoxymethyl) guanine monophosphate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.