Method for treating tumors with cis-diammineplatinum(II) orthophosphate complexes
AssigneeEngelhard Minerals & Chemicals Corporation
InventorJames D. Hoeschele
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Abstract
Cis-diammineplatinum(II) orthophosphate complexes are prepared by reaction of diaquo-cis-diammineplatinum(II) salts with alkali metal orthophosphates. The resulting complexes possess pronounced activity against tumors in mice combined with low animal toxicity.
Claims4
A method for treating malignant S180 ascites or lymphocytic leukemia P388 tumors in a mammal afflicted therewith which comprises administering to said mammal an effective amount of a cis-diammineplatinum(II) orthophosphate complex useful in the treatment of tumors, said complex comprising cis-{Pt(NH.sub.3).sub.2 } and an orthophosphate moiety of the formula:
- {(H.sub.2-n PO.sub.4)}.sup.-(1+n) wherein n is 0 or 1 and the atomic ratio of phosphorous to platinum is about 0.5-1 or about 1--1.
Dependencies are inferred from the claim text.