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US 4,287,123 AGranted
Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
AssigneeMerck & Co., Inc.
InventorsThomas M. H. Liu, David G. Melillo, Kenneth M. Ryan, Ichiro Shinkai, Meyer Sletzinger
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Abstract
Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R is a readily removable carboxyl protecting group; and ##STR2## is a readily removable acyl group.
Claims2
A compound having the structure:
- ##STR35## wherein R.sup.1 is hydrogen or a readily removable protecting group selected from alkyl having 1-6 carbon atoms, phenyl and aralkyl having 7-12 carbon atoms;
- and R.sup.4 is selected from the group consisting of hydrogen loweralkyl having 1-6 carbon atoms, phenyl and phenylloweralkyl.
Dependencies are inferred from the claim text.