Back to results
US 4,286,089 AGranted
7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
AssigneeSmithKline Corporation
InventorDavid A. Berges
Life of this patent
Estimating the term…
Abstract
The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
Claims11
A compound of the formula:
- ##STR9## in which:
- each individual R.sup.1 is hydrogen or lower alkyl of from one to four carbon atoms;
- n is one to ten;
- R.sup.2 is hydroxy, amino, lower alkylamino or di(lower)alkylamino, each alkyl having from one to four carbon atoms;
- and
- R.sup.3 is an acyl group of the formula:
- ##STR10## where:
- Z is methyl, trifluoromethyl, trifluoroethyl or pyridyl;
- and
- m is zero to two,
- or a non-toxic pharmaceutically acceptable salt thereof.
8 more elements
A compound of the formula:
- ##STR11## wherein n is one to four.
A compound of the formula:
- ##STR12## wherein n is one to four.
Dependencies are inferred from the claim text.