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US 4,285,970 AGranted
N-Phenethylaminopropiophenones as lipogenesis inhibitors
AssigneeShell Oil Company
InventorGeorge R. Haynes
Life of this patent
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Abstract
Certain N-phenethylaminopropiophenones inhibit lipogenesis in mammals.
Claims1
A method of inhibiting lipogenesis in a mammal, which comprises administering, to a mammal in need of such treatment, orally or parenterally a lipogenesis inhibiting amount of a compound of the formula:
- ##STR2## wherein R is hydrogen or hydroxyl;
- R.sup.1 is hydrogen or methyl;
- R.sup.2 is hydrogen or methyl;
- n is zero, one or two;
- X is hydroxyl, with the proviso that when n is one, the hydroxyl moiety is bonded to the carbon atom at the 4-position in the phenyl ring, and when n is two, the hydroxyl moieties are bonded to the carbon atoms in the 3- and 4-positions of the phenyl ring;
- m is one;
- Y is one of
- nitro;
- hydroxyl;
- alkyl;
- alkoxy;
- alkylthio;
- alkanoylamino;
- alkenoylamino;
- 3-(dialkylamino)alkyleneoxy;
- 2-(dialkenylamino)alkyleneoxy, and their pharmacologically acceptable acid addition salts.
13 more elements
Dependencies are inferred from the claim text.