Novel derivatives of C-076 compounds
AssigneeMerck & Co., Inc.
InventorsByron H. Arison, Robert T. Goegelman, Vincent P. Gullo
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Abstract
There are disclosed certain new derivatives of C-076 compounds which have been isolated from the fermentation broth that produced the original C-076 compounds. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Claims9
A compound having the formula:
- ##STR5## wherein (a) R.sub.1 is --OH and R.sub.2 is sec-butyl;
- (b) R.sub.1 is .dbd.O and R.sub.2 is sec-butyl;
- (c) and R.sub.1 is --OH and R.sub.2 is iso-propyl.
A compound having the formula:
- ##STR6## wherein R.sub.3 is hydrogen of hydroxyl.
Dependencies are inferred from the claim text.