1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
AssigneeRichardson-Merrell Inc.
InventorsAlbert A. Carr, Joseph E. Dolfini, George J. Wright
Life of this patent
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Abstract
Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and A and B are individually hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable acid addition salts thereof.
Claims12
A compound of the formula ##STR11## wherein R.sub.1 is hydrogen or hydroxy;
- R.sub.2 is hydrogen;
- or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;
- n is an integer of from 1 to 5;
- R.sub.3 is --CH.sub.3, or --CH.sub.2 OH;
- and A and B are individually hydrogen or hydroxy;
- with the provisos that at least one of A or B is hydrogen, and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ;
- and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.