1,4-Dihydropyridinecarboxylic acids
AssigneeBayer Aktiengesellschaft
InventorsEgbert Wehinger, Friedrich Bossert
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Abstract
The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10.degree. to 100.degree. C., of an ester group which contains an electron-attracting group. The invention also includes novel compounds made according to the invention as well as compositions containing said novel compounds. Also included in the invention are methods for the use of said compounds and compositions. The compounds obtained according to the process of the invention are useful because of their circulation-influencing action and are also useful as intermediates for the preparation of compounds having circulation-influencing action.
Claims15
A compound of the formula ##STR22## or a salt thereof, in which R denotes a 2-nitrophenyl radical, a 3-nitrophenyl radical, a 2-trifluoromethylphenyl radical, a 2-chlorophenyl radical or a 2-methylmercaptopyridyl radical,
- R.sup.1 and R.sup.2 denotes methyl groups and
- X denotes COOH or COOR.sup.4, whereby R.sup.4 denotes a straight-chain, branched or cyclic alkyl radical with up to 6 carbon atoms, which is optionally interrupted by an oxygen atom in the chain or is substituted by 1 to 2 trifluoromethyl groups or by an ##STR23## but R.sup.4 is only a methyl or isobutyl radical when R denotes a 2-nitrophenyl radical.
Dependencies are inferred from the claim text.