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US 4,285,949 AGranted
Vincamine derivatives, their preparation and therapeutical use
AssigneeOmnichem Societe Anonyme
InventorJean A. A. J. Hannart
Life of this patent
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Abstract
The new derivatives of vincamine according to this invention may be represented by the general formula ##STR1## in which R.sub.1 represents a halogen atom and R.sub.2 may represent a hydroxy group whereas R.sub.3 may represent a hydrogen atom, or R.sub.2 may form with R.sub.3 an additional bond. The compounds may be used to treat cardio-circulatory, cerebro-vascular and respiratory insufficiencies.
Claims5
A process for preparing a compound of the formula ##STR3## in which:
- R.sub.1 represents a chlorine atom in the 10-position
- R.sub.2 and R.sub.3 represent together an additional carbon-carbon bond which comprises the steps of:
- (a) reacting tabersonine with hydrochloric acid in solution in an alcohol for 2-4 days at room temperature in the presence of a peracid selected from the group consisting of m-chloroperbenzoic acid, perphthalic acid and p-nitroperbenzoic acid,
- (b) heating the resulting compound of formula I wherein R.sub.2 and R.sub.3 represent respectively OH and H in formic acid at 99%.
1 more element
Dependencies are inferred from the claim text.