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US 4,285,878 AGranted
N-Phenyl-N'-cyano-O-phenylisoureas
AssigneeSmithKline Corporation
InventorsClifford S. Labaw, Robert L. Webb
Life of this patent
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Abstract
N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benzoxazole compounds having anthelmintic activity.
Claims7
A compound of the formula:
- ##STR4## in which R is amino or hydroxy and R.sub.1 is hydrogen, acetyl, halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkyl sulfinyl, phenylthio, phenyloxy, phenylsulfinyl, cyclohexylthio, cyclohexyloxy, cyclohexylsulfinyl or thienylcarbonyl, said lower alkyl and lower alkoxy groups having 1-6 carbons.
Dependencies are inferred from the claim text.