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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsCsaba Szantay, Lajos Szabo, Gyorgy Kalaus, Lajos Dancsi, Tibor Keve, Ferenc Drexler
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The invention relates to new, racemic or optically active, halogenated 15-hydroxy-E-homoeburnane derivatives of the general formula (Ia) and/or (Ib), ##STR1## wherin R is a C.sub.1-6 alkyl group and X is halogen, and acid addition salts thereof. These compounds are biologically active, furthermore they can be applied as intermediates in the synthesis of other pharmaceutically active substances. The compounds of the general formulae (Ia) and (Ib) are prepared by halogenating the respective racemic or optically active 15-hydroxy-E-homoeburnane derivative of the general formula (II), wherein R is as defined above. ##STR2##
A process for the preparation of a racemic or optically active compound of the formulae (Ia) or (Ib), ##STR5## wherein R is C.sub.1-6 alkyl and X is halogen, which comprises reacting a racemic or optically active 15-hydroxy-E-homoeburnane derivative of the formula (II), ##STR6## wherein R is as defined above;
Dependencies are inferred from the claim text.