Cyclic analogues of callidine
OwnerGunar I. Chipens, Felix K. Mutulis +2inventors
InventorsGunar I. Chipens, Felix K. Mutulis, Olga E. Lando, Natalia V. Myshlyakova
Life of this patent
Estimating the term…
Abstract
Novel cyclic analogues of callidine have the following general formula: ##STR1## wherein Pro is moiety of L-proline, Gly--that of glycine, Phe--phenylalanine, Arg--L-argenine; R is a residue of .alpha.- or .omega.-aminoacid or peptide; R.sub.1 is a residue of .alpha.- or .omega.- amino-acid; R.sub.2 is L-serine or glycine, the carbonyl group of arginine being connected either with R or with R.sub.1 by means of a covalent peptide bond using the .omega.-amino group of the aminoacid located in the 1 or 2 position of the calladine sequence. The novel compounds according to the present invention possess a prolonged hypotensive effect of selective character.
Claims5
Cyclic analogues of callidine of the formula:
- ##STR7## wherein Pro is a moiety of L-proline, Gly - that of glycine, Phe is a moiety of L-phenylalanine;
- Arg - that of L-arginine;
- R is a residue of .alpha.- or .omega.-lysine or arginine;
- R.sub.1 is a residue or .alpha.- or .omega.-lysine or arginine;
- R.sub.2 is L-serine, and the carbonyl group of arginine is connected with either R or R.sub.1 by means of a covalent peptide bond using the .omega.-amino group of the R or R.sub.1 located at 1 or 2 position of callidine.
Dependencies are inferred from the claim text.